ChloroquineV1, Main, Exploration, bibRecord, 001E96

C3‐induced 3LL cell proliferation is mediated by C kinase

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C3‐induced 3LL cell proliferation is mediated by C kinase

Auteurs : Agostina Longo [Italie] ; Roberto Gradini [Italie] ; Vincenzo Mattei [Italie] ; Emanuela Morgante [Italie] ; Patrizio Sale [Italie] ; Marco Tafani [Italie] ; Marcella Lipari [Italie] ; Giuseppe M. Pontieri [Italie] ; Matteo A. Russo [Italie]

Source :

Journal of Cellular Biochemistry [ 0730-2312 ] ; 2005-02-15.

RBID : ISTEX:DA172AFD7ABC36CBAE522EE75DE19BE6F13974C1

Abstract

It has been demonstrated that the third component of complement (C3)1 and its peptides increase normal and tumour cell proliferation. However, the signal cascade responsible for this phenomenon is still unknown. In this study, we elucidate some of the mechanisms involved in the signalling of C3 stimulation of cell proliferation. We have first investigated the in and out traffic of C3 peptides, then we have identified the subcellular localisation of internalised C3 and, finally, we have explored the role of protein phosphorylation in C3 traffic and in the proliferation of the Lewis lung carcinoma (3LL) cells. Our results indicate that traffic of C3 is not dependent on cytoskeletal integrity and requires protein kinase C‐dependent phosphorylation. In addition, proliferation of 3LL cells stimulated by C3 depends on both C3 internalisation and protein‐kinase C phosphorylation. © 2004 Wiley‐Liss, Inc.

Url:

https://api.istex.fr/ark:/67375/WNG-0K233H3R-6/fulltext.pdf

DOI: 10.1002/jcb.20336

Affiliations:

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Le document en format XML

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<front><div type="abstract" xml:lang="en">It has been demonstrated that the third component of complement (C3)1 and its peptides increase normal and tumour cell proliferation. However, the signal cascade responsible for this phenomenon is still unknown. In this study, we elucidate some of the mechanisms involved in the signalling of C3 stimulation of cell proliferation. We have first investigated the in and out traffic of C3 peptides, then we have identified the subcellular localisation of internalised C3 and, finally, we have explored the role of protein phosphorylation in C3 traffic and in the proliferation of the Lewis lung carcinoma (3LL) cells. Our results indicate that traffic of C3 is not dependent on cytoskeletal integrity and requires protein kinase C‐dependent phosphorylation. In addition, proliferation of 3LL cells stimulated by C3 depends on both C3 internalisation and protein‐kinase C phosphorylation. © 2004 Wiley‐Liss, Inc.</div>
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C3‐induced 3LL cell proliferation is mediated by C kinase

C3‐induced 3LL cell proliferation is mediated by C kinase

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Abstract

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